Nursing Certification · CPHON

ONCC Certified Pediatric Hematology Oncology Nurse Examination Practice Test

Pediatric hematology-oncology nursing applies child-focused assessment and supportive care to cancer and blood disorders. Practice-bank questions sample decisions involving chemotherapy effects, oral mucositis, diarrhea, glucose changes, central venous catheter infection prevention, transfusion safety, and bleeding risks. They also touch on caregiver guidance, procedure preparation, and preventive medication during treatment.

Exam overview

Exam providerOncology Nursing Certification Corporation
Exam codeCPHON
CategoryNursing Certification

About the ONCC Certified Pediatric Hematology Oncology Nurse Examination Exam

Care in this area requires recognizing changes that may signal treatment toxicity or an urgent complication, then communicating findings and following an appropriate care plan. Relevant clinical tasks include assessing symptoms such as diarrhea and painful mucositis, monitoring for corticosteroid-related effects, and reinforcing infection-prevention measures for tunneled central venous catheters. Nurses also help prepare children for procedures such as lumbar puncture, provide developmentally appropriate support for anxiety, and verify essential safety steps before transfusion. Hematology knowledge is important when a child with a bleeding disorder sustains a potentially serious injury, even if symptoms are not initially apparent. Caregiver teaching connects these decisions to home observation, medication use, and timely contact with the clinical team. The available question set samples these concepts but does not establish official exam domains or their relative emphasis.

Sample Practice Questions

Review a selection from this exam's published US Practice Tests practice bank.

Question 1

A child receiving chemotherapy has painful oral mucositis. Which care measure is most appropriate?

  1. AUse an alcohol-based mouthwash after meals
  2. BOffer gentle oral care with a soft toothbrush and bland rinses
  3. CEncourage acidic drinks to stimulate saliva
  4. DWithhold oral hygiene until the mucosa heals
Show answerCorrect answer: B

Gentle, regular oral care with a soft toothbrush and bland rinses can help maintain comfort and reduce complications. Alcohol-containing rinses and acidic foods or drinks may irritate damaged mucosa; oral hygiene should not be stopped.

Question 2

A child with cancer has a tunneled central venous catheter. Which caregiver action best reduces infection risk during routine catheter care?

  1. AClean the connection using the recommended antiseptic and allow it to dry before access
  2. BTouch the cleaned connection briefly to check that it is dry
  3. CReuse a syringe if it has been kept in a clean medication area
  4. DAccess the line without hand hygiene when gloves are worn
Show answerCorrect answer: A

Hand hygiene, aseptic technique, and appropriate antiseptic disinfection with adequate drying time are key measures for preventing catheter-related infection. Gloves do not replace hand hygiene, and syringes must not be reused.

Question 3

A child receiving chemotherapy has a markedly elevated serum glucose level. Which treatment-related factor is a recognized cause of hyperglycemia?

  1. ACorticosteroid therapy
  2. BOral iron supplementation
  3. CTopical emollient use
  4. DRoutine saline mouth rinses
Show answerCorrect answer: A

Corticosteroids can increase blood glucose by affecting glucose metabolism. Children receiving these medicines may need glucose monitoring and clinical follow-up according to their treatment plan.

Question 4

A child receiving chemotherapy has new diarrhea. Which caregiver instruction is most appropriate while the clinical team evaluates the symptom?

  1. ARecord the number and character of stools and report worsening symptoms or signs of dehydration.
  2. BGive an over-the-counter antidiarrheal medication without contacting the care team.
  3. CStop all fluids until the diarrhea resolves.
  4. DAssume diarrhea is expected and mention it only at the next routine visit.
Show answerCorrect answer: A

Tracking stool frequency and characteristics helps assess severity and possible causes. Prompt reporting of worsening symptoms or dehydration is important; medication and fluid guidance should follow the child's clinical plan.

Question 5

A caregiver asks how to support a child who is anxious about an upcoming procedure. Which nursing response is most helpful?

  1. AOffer developmentally appropriate preparation and choices the child can safely control
  2. BPromise the procedure will not hurt
  3. CAvoid discussing the procedure until it is over
  4. DTell the child that anxiety is inappropriate
Show answerCorrect answer: A

Developmentally appropriate information, supportive preparation, and limited meaningful choices can help children feel safer and more involved. False reassurance and dismissing or concealing concerns can undermine trust.

Question 6

A child with cancer is scheduled for a lumbar puncture. Which position commonly helps the clinician access the lower lumbar space?

  1. ASide-lying with the back flexed, if tolerated
  2. BProne with the neck extended
  3. CStanding with knees locked
  4. DSupine with the hips fully extended
Show answerCorrect answer: A

A flexed side-lying position can widen the spaces between lumbar vertebrae and facilitate lumbar puncture. The child’s condition and procedural requirements may call for a different position, and staff should support the child and follow the clinician’s instructions.

Question 7

A child with cancer is scheduled to receive a blood transfusion. Which action is essential immediately before starting the transfusion?

  1. AVerify the blood product and patient identity with the required independent checks
  2. BWarm the blood product in a microwave
  3. CAsk the child to walk to assess baseline endurance
  4. DAdd medication directly to the blood bag
Show answerCorrect answer: A

Correct patient and blood-product identification using the institution’s required verification process is a critical transfusion-safety step. Blood products must not be microwaved or mixed with medications in the bag.

How to use this practice test

Access the free practice set to work through up to 20 randomly selected questions from the 50-question bank. After the session, review the results to identify which sampled decisions need more attention, such as treatment-related symptom assessment, catheter care, transfusion safety, or caregiver instructions.

Preparation tips

  • For chemotherapy-related symptoms, distinguish findings that require prompt clinical evaluation from supportive measures caregivers can use while awaiting guidance.
  • Review tunneled central venous catheter infection-prevention steps, including clean technique during routine care and signs that should be reported.
  • Rehearse transfusion safety checks and baseline assessment tasks that must occur before blood products are started.
  • Connect corticosteroid treatment with possible effects such as elevated glucose, and consider what monitoring findings should be communicated.
  • For pediatric bleeding disorders, treat significant head injury as potentially serious even when the child initially appears well; focus on urgent caregiver guidance.
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